A new simple, sensitive, rapid, accurate, precise and economical first derivative Spectrophotometric method for the simultaneous determination of cilnidipine (CIL) and metoprolol succinate (METO) in combined pharmaceutical formulation was developed. The derivative spectrophotometric method was based on the determination of both the drugs at their respective zero crossing point (ZCP). The first order derivative spectrums were obtained in methanol and the determinations were made at 241.13 nm (ZCP of CIL) for quantification of METO and 275.22 nm (ZCP of METO) for quantification of CIL. The linearity was obtained in the concentration range of 2-10 μg/ml for CIL and 10-50 μg/ml for METO. The mean recovery was 99.58% – 100.83% and 98.66% – 99.66% for CIL and METO respectively. The results of analysis have been validated statistically as per ICH guidelines.
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